Click and drag to rotate
RSV Fusion Glycoprotein Prefusion 5TDL 3d printed

Not a Photo

Glossy Full Color Sandstone
RSV Fusion Glycoprotein Prefusion 5TDL 3d printed
RSV Fusion Glycoprotein Prefusion 5TDL 3d printed

Not a Photo

RSV Fusion Glycoprotein Prefusion 5TDL

Made by
Print With Shapeways
Choose Your Size
Choose Your Material
Choose your color and finish

Have a question about this product?

contact the designer
You must be logged in and verified to contact the designer.
Product Description
<span style="font-size:14px;">Bovine respiratory syncytial virus, a major cause of respiratory disease in calves, is closely related to human RSV, a leading cause of respiratory disease in infants. Recently, promising human RSV-vaccine candidates have been engineered that stabilize the metastable fusion (F) glycoprotein in its prefusion state; however, the absence of a relevant animal model for human RSV has complicated assessment of these vaccine candidates. Here, we use a combination of structure-based design, antigenic characterization, and X-ray crystallography to translate human RSV F stabilization into the bovine context. A "DS2" version of bovine respiratory syncytial virus F with subunits covalently fused, fusion peptide removed, and pre-fusion conformation stabilized by cavity-filling mutations and intra- and inter-protomer disulfides was recognized by pre-fusion-specific antibodies, AM14, D25, and MPE8, and elicited bovine respiratory syncytial virus-neutralizing titers in calves >100-fold higher than those elicited by post-fusion F. When challenged with a heterologous bovine respiratory syncytial virus, virus was not detected in nasal secretions nor in respiratory tract samples of DS2-immunized calves; by contrast bovine respiratory syncytial virus was detected in all post-fusion- and placebo-immunized calves. Our results demonstrate proof-of-concept that DS2-stabilized RSV F immunogens can induce highly protective immunity from RSV in a native host with implications for the efficacy of prefusion-stabilized F vaccines in humans and for the prevention of bovine respiratory syncytial virus in calves. </span><br />
What's in the box:
3.47 x 5.34 x 3.69 cm
Switch to inches
1.37 x 2.1 x 1.45 inches
Switch to cm
Success Rate:
First To try.
What's this?
Mature audiences only.


We're sorry to inform you that we no longer support this browser and can't confirm that everything will work as expected. For the best Shapeways experience, please use one of the following browsers:

Click anywhere outside this window to continue.