Click and drag to rotate
Angiopoietin-2/Tie2 Complex 3d printed

DIGITAL PREVIEW
Not a Photo

Glossy Full Color Sandstone
Angiopoietin-2/Tie2 Complex 3d printed
Angiopoietin-2/Tie2 Complex 3d printed

DIGITAL PREVIEW
Not a Photo

Angiopoietin-2/Tie2 Complex

Made by
$37.68
3D printed in fully colored material with a glossy and smooth finish.
QTY

Have a question about this product?

contact the designer
You must be logged in and verified to contact the designer.
Product Description
Model Description
This is a 3D printed model of Angiopoietin-2/Tie2 Complex created from PDB ID: 
2gy7​
Protein Description
The Tie receptor tyrosine kinases and their angiopoietin (Ang) ligands play central roles in developmental and tumor-induced angiogenesis. Here we present the crystal structures of the Tie2 ligand-binding region alone and in complex with Ang2. In contrast to prediction, Tie2 contains not two but three immunoglobulin (Ig) domains, which fold together with the three epidermal growth factor domains into a compact, arrowhead-shaped structure. Ang2 binds at the tip of the arrowhead utilizing a lock-and-key mode of ligand recognition-unique for a receptor kinase-where two complementary surfaces interact with each other with no domain rearrangements and little conformational change in either molecule. Ang2-Tie2 recognition is similar to antibody-protein antigen recognition, including the location of the ligand-binding site within the Ig fold. Analysis of the structures and structure-based mutagenesis provide insight into the mechanism of receptor activation and support the hypothesis that all angiopoietins interact with Tie2 in a structurally similar manner.
Details
What's in the box:
sml_tie2ang2_2gy7_x50
Dimensions:
3.36 x 6.14 x 2.95 cm
Switch to inches
1.32 x 2.42 x 1.16 inches
Switch to cm
Success Rate:
First To try.
What's this?
Rating:
Mature audiences only.
Sign In or Join to comment.
 
 
Logo

Hello.

We're sorry to inform you that we no longer support this browser and can't confirm that everything will work as expected. For the best Shapeways experience, please use one of the following browsers:

Click anywhere outside this window to continue.