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EGFR Active Mutant Tyrosine Kinase 3d printed

DIGITAL PREVIEW
Not a Photo

Coated Full Color Sandstone
EGFR Active Mutant Tyrosine Kinase 3d printed
EGFR Active Mutant Tyrosine Kinase 3d printed

DIGITAL PREVIEW
Not a Photo

EGFR Active Mutant Tyrosine Kinase

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  • 3D printed in Coated Full Color Sandstone: Fully colored material with a glossy and smooth finish.
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  • This product is intended for mature audiences.
$34.29
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Product Description

"The epidermal growth factor receptor (EGFR) family plays a critical role in vital cellular processes and in various cancers. Known EGFR inhibitors exhibit distinct antitumor responses against the various EGFR mutants associated with nonsmall-cell lung cancer. The L858R mutation enhances clinical sensitivity to gefitinib and erlotinib as compared with wild type and reduces the relative sensitivity to lapatinib. In contrast, the T790M mutation confers drug resistance to gefitinib and erlotinib. We determined crystal structures of the wild-type and T790M/L858R double mutant EGFR kinases with reversible and irreversible pyrrolo[3,2-d]pyrimidine inhibitors based on analogues of TAK-285 and neratinib. In these structures, M790 adopts distinct conformations to accommodate different inhibitors, whereas R858 allows conformational variations of the activation loop. These results provide structural insights for understanding the structure-activity relationships that should contribute to the development of potent inhibitors against drug-sensitive or -resistant EGFR mutations."

http://www.ncbi.nlm.nih.gov/pubmed/24900643

    
What's in the Box
INCM
Sml: Egfr Mutant
Coated Full Color Sandstone
Width
3.3 cm
Height
4.0 cm
Depth
2.8 cm

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