Just a few days left to Make Your Holiday!
Check order deadlines

<div class="sw-email-modal sw--display-block"> <div id="emailModalContentContainer"> <span class="noty_close sw--position-absolute sw--position-right sw--padding-top-3 sw--padding-right-3 icon-cancel sw--opacity-8"></span> <div class="sw-row"> <div class="sw-email-modal__copy sw--position-relative sw--display-block sw--padding-vert-4"> <p class="last sw--font-size-16">Sign up to get email alerts on discount promotions. There might be one very soon...</p> <form action="/register/email-signup" class="sw-email-modal__signup sw--position-relative" data-confirmation="emailConfirmationModal" data-sw-email-modal-form> <input type="text" class="sw-email-modal__signup-input sw--input-height__medium" placeholder="Email address" name="email" /> <input type="hidden" class="sw-email-modal__signup-input" name="location" value="/product/F4GGZGJCJ/parp1-bound-by-zejula" /> <input type="hidden" class="sw-email-modal__signup-input" name="confirmation" value="emailConfirmationModal" /> <input type="submit" class="btn-primary" value="Sign Up" /> <div id="emailModalFormError" class="text-error" style="display:none"></div> </form> </div> </div> </div>

Click and drag to rotate
PARP1 bound by Zejula 3d printed

DIGITAL PREVIEW
Not a Photo

Coated Full Color Sandstone
PARP1 bound by Zejula 3d printed
PARP1 bound by Zejula 3d printed

DIGITAL PREVIEW
Not a Photo

PARP1 bound by Zejula

Made By
Size
OVERVIEW
  • 3D printed in Coated Full Color Sandstone: Fully colored material with a glossy and smooth finish.
  • Be the first to try. Learn more
  • This product is intended for mature audiences.
$27.42
1
0
Share Link
Embed This Product

Product Description

"Selective inhibitors could help unveil the mechanisms by which inhibition of poly(ADP-ribose) polymerases (PARPs) elicits clinical benefits in cancer therapy. We profiled 10 clinical PARP inhibitors and commonly used research tools for their inhibition of multiple PARP enzymes. We also determined crystal structures of these compounds bound to PARP1 or PARP2. Veliparib and niraparib are selective inhibitors of PARP1 and PARP2; olaparib, rucaparib, and talazoparib are more potent inhibitors of PARP1 but are less selective. PJ34 and UPF1069 are broad PARP inhibitors; PJ34 inserts a flexible moiety into hydrophobic subpockets in various ADP-ribosyltransferases. XAV939 is a promiscuous tankyrase inhibitor and a potent inhibitor of PARP1 in vitro and in cells, whereas IWR1 and AZ-6102 are tankyrase selective. Our biochemical and structural analysis of PARP inhibitor potencies establishes a molecular basis for either selectivity or promiscuity and provides a benchmark for experimental design in assessment of PARP inhibitor effects. "
http://www.rcsb.org/pdb/explore.do?structureId=4r6e
What's in the Box
INCM
Sml: PARP1 Zejula
Coated Full Color Sandstone
Width
4.1 cm
Height
4.6 cm
Depth
3.5 cm

Sign In or Join to comment.
 
 
Logo

Hello.

We're sorry to inform you that we no longer support this browser and can't confirm that everything will work as expected. For the best Shapeways experience, please use one of the following browsers:

Click anywhere outside this window to continue.