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PARP1 bound by Zejula 3d printed

DIGITAL PREVIEW
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Glossy Full Color Sandstone
PARP1 bound by Zejula 3d printed
PARP1 bound by Zejula 3d printed

DIGITAL PREVIEW
Not a Photo

PARP1 bound by Zejula

Made by
$34.42
3D printed in fully colored material with a glossy and smooth finish.
QTY
Product Description
"Selective inhibitors could help unveil the mechanisms by which inhibition of poly(ADP-ribose) polymerases (PARPs) elicits clinical benefits in cancer therapy. We profiled 10 clinical PARP inhibitors and commonly used research tools for their inhibition of multiple PARP enzymes. We also determined crystal structures of these compounds bound to PARP1 or PARP2. Veliparib and niraparib are selective inhibitors of PARP1 and PARP2; olaparib, rucaparib, and talazoparib are more potent inhibitors of PARP1 but are less selective. PJ34 and UPF1069 are broad PARP inhibitors; PJ34 inserts a flexible moiety into hydrophobic subpockets in various ADP-ribosyltransferases. XAV939 is a promiscuous tankyrase inhibitor and a potent inhibitor of PARP1 in vitro and in cells, whereas IWR1 and AZ-6102 are tankyrase selective. Our biochemical and structural analysis of PARP inhibitor potencies establishes a molecular basis for either selectivity or promiscuity and provides a benchmark for experimental design in assessment of PARP inhibitor effects. "
http://www.rcsb.org/pdb/explore.do?structureId=4r6e
Details
What's in the box:
Sml: PARP1 Zejula
Dimensions:
4.09 x 4.6 x 3.53 cm
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1.61 x 1.81 x 1.39 inches
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Success Rate:
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Rating:
Mature audiences only.
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