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Apaf-1 Caspase 9 5WVE 3d printed

Not a Photo

Glossy Full Color Sandstone
Apaf-1 Caspase 9 5WVE 3d printed
Apaf-1 Caspase 9 5WVE 3d printed

Not a Photo

Apaf-1 Caspase 9 5WVE

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3D printed in fully colored material with a glossy and smooth finish.

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Product Description
Model Description
This 3D printed protein model of Apaf-1 Caspase 9 is visualized as a volumetric surface and colored to visualize each chain uniquely. This 3D protein model was created from PDB ID: 5WVE.
Protein Description
Mammalian intrinsic apoptosis requires activation of the initiator caspase-9, which then cleaves and activates the effector caspases to execute cell killing. The heptameric Apaf-1 apoptosome is indispensable for caspase-9 activation by together forming a holoenzyme. The molecular mechanism of caspase-9 activation remains largely enigmatic. Here, we report the cryoelectron microscopy (cryo-EM) structure of an apoptotic holoenzyme and structure-guided biochemical analyses. The caspase recruitment domains (CARDs) of Apaf-1 and caspase-9 assemble in two different ways: a 4:4 complex docks onto the central hub of the apoptosome, and a 2:1 complex binds the periphery of the central hub. The interface between the CARD complex and the central hub is required for caspase-9 activation within the holoenzyme. Unexpectedly, the CARD of free caspase-9 strongly inhibits its proteolytic activity. These structural and biochemical findings demonstrate that the apoptosome activates caspase-9 at least in part through sequestration of the inhibitory CARD domain.
What's in the box:
Sml: Apaf-1-Caspase-9
7.22 x 3.37 x 7.34 cm
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2.84 x 1.33 x 2.89 inches
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Mature audiences only.


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