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ArcAB-TolC Efflux Pump 3d printed

Not a Photo

Glossy Full Color Sandstone
ArcAB-TolC Efflux Pump  3d printed
ArcAB-TolC Efflux Pump  3d printed

Not a Photo

ArcAB-TolC Efflux Pump

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Product Description
Model Description
This is a 3D printed Biologic Model of a Bacterial ArcAB-TolC Efflux Pump colored to match the academic publication  An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump .

PubMed Abstract
Bacterial efflux pumps confer multidrug resistance by transporting diverse antibiotics from the cell. In Gram-negative bacteria, some of these pumps form multi-protein assemblies that span the cell envelope. Here, we report the near-atomic resolution cryoEM structures of the Escherichia coli AcrAB-TolC multidrug efflux pump in resting and drug transport states, revealing a quaternary structural switch that allosterically couples and synchronizes initial ligand binding with channel opening. Within the transport-activated state, the channel remains open even though the pump cycles through three distinct conformations. Collectively, our data provide a dynamic mechanism for the assembly and operation of the AcrAB-TolC pump.

What's in the box:
2.92 x 8.06 x 3.18 cm
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1.15 x 3.17 x 1.25 inches
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Mature audiences only.


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