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Neurotensen Receptor 4GRV 3d printed

DIGITAL PREVIEW
Not a Photo

Glossy Full Color Sandstone
Neurotensen Receptor 4GRV 3d printed
Neurotensen Receptor 4GRV 3d printed

DIGITAL PREVIEW
Not a Photo

Neurotensen Receptor 4GRV

Made by
$38.26
3D printed in fully colored material with a glossy and smooth finish.
QTY
Product Description
3D printed protein model of a Neurotensin Receptor created from PDB ID: 4GRV.
Model Description
This is a 3D printed protein model of a Neurotensin Receptor colored by the protein's hydrophobicity.
Protein Description
Neurotensin (NTS) is a 13-amino-acid peptide that functions as both a neurotransmitter and a hormone through the activation of the neurotensin receptor NTSR1, a G-protein-coupled receptor (GPCR). In the brain, NTS modulates the activity of dopaminergic systems, opioid-independent analgesia, and the inhibition of food intake; in the gut, NTS regulates a range of digestive processes. Here we present the structure at 2.8 Å resolution of Rattus norvegicus NTSR1 in an active-like state, bound to NTS(8-13), the carboxy-terminal portion of NTS responsible for agonist-induced activation of the receptor. The peptide agonist binds to NTSR1 in an extended conformation nearly perpendicular to the membrane plane, with the C terminus oriented towards the receptor core. Our findings provide, to our knowledge, the first insight into the binding mode of a peptide agonist to a GPCR and may support the development of non-peptide ligands that could be useful in the treatment of neurological disorders, cancer and obesity.
https://www.rcsb.org/structure/4GRV
Details
What's in the box:
sml_neurotensionR_4GRV_max_2_x45
Dimensions:
3.96 x 6.62 x 2.77 cm
Switch to inches
1.56 x 2.61 x 1.09 inches
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Success Rate:
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Rating:
Mature audiences only.
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