Click and drag to rotate
Asparaginase 3d printed

DIGITAL PREVIEW
Not a Photo

Glossy Full Color Sandstone
Asparaginase  3d printed
Asparaginase  3d printed

DIGITAL PREVIEW
Not a Photo

Asparaginase

Made by
$30.57
3D printed in fully colored material with a glossy and smooth finish.
QTY

Have a question about this product?

contact the designer
You must be logged in and verified to contact the designer.
Product Description
Model Description
This 3D printed protein model of Asparaginase created from PDB ID: 5MQ5. Asparaginase exists as both a monomer (single Asparaginase) and dimer (two bound Asparaginase). The monomer is colored green by the protein's bFactor, yellow-green the hottest and blue-green the coolest.  Mutation N24S is colored orange-red.
Protein Description
Asparaginase is an enzyme from Escherichia coli involved in intracellular asparagine utilization. It's also used in different industries as a medication and in food manufacturing. Asparaginase is administered subcutaneously, and its half-life is problematic for long-term storage. This 3D printed protein model of Asparaginase identifies an engineered mutation that extends the protein's half-life.

L-Asparaginases (ASNases) have been used as first-line drugs for pediatric Acute Lymphoblastic Leukaemia (ALL) treatment for more than 40 years. Both the Escherichia coli (EcAII) and Erwinia chrysanthemi (ErAII) type II ASNases currently used in the clinics are characterized by high in vivo instability, short half-life and the requirement of several administrations to obtain a pharmacologically active concentration. Moreover, they are sensitive to proteases (cathepsin B and asparagine endopeptidase) that are over-expressed by resistant leukemia lymphoblasts, thereby impairing drug activity and pharmacokinetics. Herein, we present the biochemical, structural and in vitro antiproliferative characterization of a new EcAII variant, N24S. The mutant shows completely preserved asparaginase and glutaminase activities, long-term storage stability, improved thermal parameters, and outstanding resistance to proteases derived from leukaemia cells. Structural analysis demonstrates a modification in the hydrogen bond network related to residue 24, while Normal Mode-based geometric Simulation and Molecular Dynamics predict a general rigidification of the monomer as compared to wild-type. These improved features render N24S a potential alternative treatment to reduce the number of drug administrations in vivo and to successfully address one of the major current challenges of ALL treatment: spontaneous, protease-dependent and immunological inactivation of ASNase.
https://www.rcsb.org/structure/5MQ5
Details
What's in the box:
ExSml: Asparaginase_5mq5_ml_v3_55
Dimensions:
3.58 x 2.64 x 2.4 cm
Switch to inches
1.41 x 1.04 x 0.95 inches
Switch to cm
Success Rate:
First To try.
What's this?
Rating:
Mature audiences only.
Sign In or Join to comment.
 
 
Logo

Hello.

We're sorry to inform you that we no longer support this browser and can't confirm that everything will work as expected. For the best Shapeways experience, please use one of the following browsers:

Click anywhere outside this window to continue.