3D print of Bruton's Tyrosine Kinase in complex with small molecule inhibitor GDC-0834 created from PDB ID: 5P9K .
The protein is colored according to the protein's bFactor, or atomic heat. Colored organe is the protein's active loop, a-loop, which displays an inactive conformation.
"Bruton's tyrosine kinase (abbreviated Btk or BTK) also known as tyrosine-protein kinase BTK is an enzyme that in humans is encoded by the BTK gene. BTK is a kinase that plays a crucial role in B-cell development. BTK plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor that modulate the activity of downstream proteins during B-cell signalling.
Mutations in the BTK gene are implicated in the primary immunodeficiency disease X-linked agammaglobulinemia (Bruton's agammaglobulinemia); sometimes abbreviated to XLA. Patients with XLA have normal pre-B cell populations in their bone marrow but these cells fail to mature and enter the circulation. The Btk gene is located on the X chromosome. At least 400 mutations of the BTK gene have been identified."