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Bruton's Tyrosine Kinase bound by GDC-0834 5P9K 3d printed

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Bruton's Tyrosine Kinase bound by GDC-0834 5P9K 3d printed
Bruton's Tyrosine Kinase bound by GDC-0834 5P9K 3d printed

Not a Photo

Bruton's Tyrosine Kinase bound by GDC-0834 5P9K

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Product Description
3D print of Bruton's Tyrosine Kinase in complex with small molecule inhibitor GDC-0834 created from PDB ID: 5P9K .

Model Description
The protein is colored according to the protein's bFactor, or atomic heat. Colored organe is the protein's active loop, a-loop, which displays an inactive conformation. 

Protein Description
"Bruton's tyrosine kinase (abbreviated Btk or BTK) also known as tyrosine-protein kinase BTK is an enzyme that in humans is encoded by the BTK gene. BTK is a kinase that plays a crucial role in B-cell development. BTK plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor that modulate the activity of downstream proteins during B-cell signalling.

Mutations in the BTK gene are implicated in the 
primary immunodeficiency disease X-linked agammaglobulinemia (Bruton's agammaglobulinemia); sometimes abbreviated to XLA. Patients with XLA have normal pre-B cell populations in their bone marrow but these cells fail to mature and enter the circulation. The Btk gene is located on the X chromosome.[5] At least 400 mutations of the BTK gene have been identified."'s_tyrosine_kinase
What's in the box:
Sml: 4otf BtkLigand
2.91 x 3.83 x 2.76 cm
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1.15 x 1.51 x 1.09 inches
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