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Product Description
Members of the Small Conductance Mechanosensitive Ion Channel (MscS) Family provide protection against hypo-osmotic shock in bacteria, responding both to stretching of the cell membrane and to membrane depolarization. In eukaryotes, they fulfill a multitude of important functions in addition to osmoregulation. They are present in the membranes of organisms from the three domains of life: bacteria, archaea, fungi and plants. MS channels function as electromechanical switches with the capability to sense the physical state of lipid bilayers. Interactions with the membrane lipids are responsible for the sensing of mechanical force for most known MS channels. In bacterial and animal systems, MS ion channels are thought to mediate the perception of pressure, touch, and sound. With numerous members now electrophysiologically characterized, these channels displays a breadth of ion selectivity with both anion- and cation-selective members. The selectivities of these channels may be relatively weak in comparison to voltage-gated channels. In addition, some MscS channels may function in amino acid efflux, Ca2+ regulation and cell division.
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Small-Conductance Mechanosensitive Channel
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