Ring Finger Protein 213 6TAX

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Product Description

Ring finger protein 213 is a protein that in humans is encoded by the RNF213 gene.[5] RNF213 is a 591kDa cytosolic E3 Ubiquitin-ligase with RING finger and AAA+ ATPase domains. A genome-wide association study also identified RNF213 as a disease causing gene for Moyamoya disease.[9] Comparative evolutionary genome sequencing analyses in humans and monkeys showed that the strongest evidence for acceleration along the branch leading to hominines was RNF213.[10] RNF213 has been shown to be associated with blood flow and oxygen consumption.[11][12][13] Given that oxygen and glucose consumption scales with total neuron number, RNF213 may have played a role in facilitating the evolution of larger brains in primates.