Inner Kinetochore Protein Cep3p

Kinetochores are disc-shaped proteins found at the centromere of a chromatid, to which microtubules attach during cell division. The kinetochore is a protein structure on chromatids where the spindle fibers attach during cell division to pull sister chromatids apart. Their proteins help to hold the sister chromatids together and also play a role in chromosome editing. The kinetochore forms in eukaryotes, assembles on the centromere and links the chromosome to microtubule polymers from the mitotic spindle during mitosis and meiosis. Monocentric organisms, including vertebrates, fungi, and most plants, have a single centromeric region on each chromosome which assembles one kinetochore. Holocentric organisms, such as nematodes and some plants, assemble a kinetochore along the entire length of a chromosome. The kinetochore contains two regions: an inner kinetochore, which is tightly associated with the centromere DNA, assembled in a specialized form of chromatin persistent throughout the cell cycle; an outer kinetochore, which interacts with microtubules; the outer kinetochore is a very dynamic structure, with many identical components, which are assembled and functional only during cell division.

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