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DPP4-Sitagliptin Complex 2P8S
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Product Description
Molecular modeling was used to design a rigid analog of sitagliptin 1. The X-ray crystal structure of sitagliptin bound to DPP-4 suggested that the central beta-amino butyl amide moiety could be replaced with a cyclohexylamine group. This was confirmed by structural analysis and the resulting analog 2a was synthesized and found to be a potent DPP-4 inhibitor (IC(50)=21 nM) with excellent in vivo activity and pharmacokinetic profile.
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exsml_DPP4-Sitagliptin_2P8S_v1_max_x50-4cm
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Mature audiences only.
