Natural Full Color Sandstone
Product Description
The development of HIV integrase (IN) strand transfer inhibitors (INSTIs) and our understanding of viral resistance to these molecules have been hampered by a paucity of available structural data. We recently reported cocrystal structures of the prototype foamy virus (PFV) intasome with raltegravir and elvitegravir, establishing the general INSTI binding mode. We now present an expanded set of cocrystal structures containing PFV intasomes complexed with first- and second-generation INSTIs at resolutions of up to 2.5 Å. Importantly, the improved resolution allowed us to refine the complete coordination spheres of the catalytic metal cations within the INSTI-bound intasome active site.
Request a custom order
and get this product personalized just for you
Details
What's in the box:
Prototype Foamy Virus (PFV) Integrase
Dimensions:
Success Rate:
First To try.
What's this?
Rating:
Mature audiences only.
