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Hemoglobin ζ2 β2
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Product Description
The variant Hemoglobin ζ2 β2 that is formed from sickle hemoglobin (α2β2-s) by exchanging adult α-globin with embryonic ζ-globin subunits shows promise as a therapeutic agent for sickle-cell disease (SCD). Hemoglobin ζ2β2 inhibits the polymerization of deoxygenated Hb S in vitro and reverses characteristic features of SCD in vivo in mouse models of the disorder.
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Hemoglobin ζ2 β2
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Mature audiences only.
