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Sphingosine kinase 1 3vzb 3d printed

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Sphingosine kinase 1 3vzb 3d printed
Sphingosine kinase 1 3vzb 3d printed

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Sphingosine kinase 1 3vzb

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Product Description
Sphingosine kinase 1 (SphK1) is a lipid kinase that catalyzes the conversion of sphingosine to sphingosine-1-phosphate (S1P), which has been shown to play a role in lymphocyte trafficking, angiogenesis, and response to apoptotic stimuli. As a central enzyme in modulating the S1P levels in cells, SphK1 emerges as an important regulator for diverse cellular functions and a potential target for drug discovery. Here, we present the crystal structures of human SphK1 in the apo form and in complexes with a substrate sphingosine-like lipid, ADP, and an inhibitor at 2.0-2.3 Å resolution. The SphK1 structures reveal a two-domain architecture in which its catalytic site is located in the cleft between the two domains and a hydrophobic lipid-binding pocket is buried in the C-terminal domain. Comparative analysis of these structures with mutagenesis and kinetic studies provides insight into how SphK1 recognizes the lipid substrate and catalyzes ATP-dependent phosphorylation.
http://www.rcsb.org/pdb/explore.do?structureId=3vzb
Details
What's in the box:
Sml: sphingosine_kinase_1
Dimensions:
3.21 x 3.88 x 2.94 cm
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1.27 x 1.53 x 1.16 inches
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Mature audiences only.