There's a very definite difference. I had some model buses printed and polished. In one orientation, the models were printed and polished perfectly, 100% quality.
However, another batch were printed with a different orientation, and as well as unsightly layering along large areas of the model, at least twenty or thirty small detail parts sheared off, leaving the models unsightly and with a lot of remedial work to do.
For the casual customer, this leaves me with a dilemna. Either I design out a lot of the small detail which gives these models their accuracy and quality, or I leave in the detail, and worry that some customers receive a very substandard model, for the same price as a 100% quality model.
I would very definitely put in a vote for choice of orientation, as it hugely affects the quality or otherwise of some very detailed models I wish to sell.