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Proteasome 1Q5R 3d printed

Not a Photo

Glossy Full Color Sandstone
Proteasome 1Q5R 3d printed
Proteasome 1Q5R 3d printed

Not a Photo

Proteasome 1Q5R

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3D printed in fully colored material with a glossy and smooth finish.

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Product Description
To understand the role of the pro-peptide in proteasome assembly, we have determined structures of the Rhodococcus proteasome and a mutant form that prevents the autocatalytic removal of its pro-peptides. The structures reveal that the pro-peptide acts as an assembly-promoting factor by linking its own beta-subunit to two adjacent alpha-subunits, thereby providing a molecular explanation for the observed kinetics of proteasome assembly. The Rhodococcus proteasome has been found to have a substantially smaller contact region between alpha-subunits compared to those regions in the proteasomes of Thermoplasma, yeast, and mammalian cells, suggesting that a smaller contact area between alpha-subunits is likely the structural basis for the Rhodococcus alpha-subunits not assembling into alpha-rings when expressed alone. Analysis of all available beta-subunit structures shows that the contact area between beta-subunits within a beta-ring is not sufficient for beta-ring self-assembly without the additional contact provided by the alpha-ring. This appears to be a fail-safe mechanism ensuring that the active sites on the beta-subunits are activated only after proteasome assembly is complete.
What's in the box:
3.15 x 3.15 x 3.97 cm
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1.24 x 1.24 x 1.57 inches
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Success Rate:
First To try.
What's this?
Mature audiences only.


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