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Ribosome Quality Control Complex 3d printed

DIGITAL PREVIEW
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Natural Full Color Sandstone
Ribosome Quality Control Complex 3d printed
Ribosome Quality Control Complex 3d printed

DIGITAL PREVIEW
Not a Photo

Ribosome Quality Control Complex

Made by
$40.00
3D printed in fully colored material with a coarse finish and a delicate feel.
QTY
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Product Description
During ribosome-associated quality control, stalled ribosomes are split into subunits and the 60S-housed nascent polypeptides are poly-ubiquitinated by Listerin. How this low-abundance ubiquitin ligase targets rare stall-generated 60S among numerous empty 60S is unknown. Here, we show that Listerin specificity for nascent chain-60S complexes depends on nuclear export mediator factor (NEMF). The 3.6 Å cryo-EM structure of a nascent chain-containing 60S-Listerin-NEMF complex revealed that NEMF makes multiple simultaneous contacts with 60S and peptidyl-tRNA to sense nascent chain occupancy. Structural and mutational analyses showed that ribosome-bound NEMF recruits and stabilizes Listerin's N-terminal domain, while Listerin's C-terminal RWD domain directly contacts the ribosome to position the adjacent ligase domain near the nascent polypeptide exit tunnel. Thus, highly specific nascent chain targeting by Listerin is imparted by the avidity gained from a multivalent network of context-specific individually weak interactions, highlighting a new principle of client recognition during protein quality control.
Details
What's in the box:
Ribosome Quality Control Complex
Dimensions:
4.55 x 5.17 x 5.44 cm
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1.79 x 2.04 x 2.14 inches
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Success Rate:
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Rating:
Mature audiences only.
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