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Depiptidyl Peptidase IV (DPP-4) in Complex with Sm 3d printed

DIGITAL PREVIEW
Not a Photo

Coated Full Color Sandstone
Depiptidyl Peptidase IV (DPP-4) in Complex with Sm 3d printed
Depiptidyl Peptidase IV (DPP-4) in Complex with Sm 3d printed

DIGITAL PREVIEW
Not a Photo

Depiptidyl Peptidase IV (DPP-4) in Complex with Sm

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  • 3D printed in Coated Full Color Sandstone: Fully colored material with a glossy and smooth finish.
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  • This product is intended for mature audiences.
$33.04
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Product Description

In recent years, various dipeptidyl peptidase IV (DPP-4) inhibitors have been released as therapeutic drugs for type 2 diabetes in many countries. In spite of their diverse chemical structures, no comparative studies of their binding modes in the active site of DPP-4 have been disclosed. We determined the co-crystal structure of vildagliptin with DPP-4 by X-ray crystallography and compared the binding modes of six launched inhibitors in DPP-4. The inhibitors were categorized into three classes on the basis of their binding subsites: (i) vildagliptin and saxagliptin (Class 1) form interactions with the core S1 and S2 subsites and a covalent bond with Ser630 in the catalytic triad; (ii) alogliptin and linagliptin (Class 2) form interactions with the S1' and/or S2' subsites in addition to the S1 and S2 subsites; and (iii) sitagliptin and teneligliptin (Class 3) form interactions with the S1, S2 and S2 extensive subsites. The present study revealed that the additional interactions with the S1', S2' or S2 extensive subsite may increase DPP-4 inhibition beyond the level afforded by the fundamental interactions with the S1 and S2 subsites and are more effective than forming a covalent bond with Ser630. 

 

    
What's in the Box
INCM
Sml: DPP4 IV
Coated Full Color Sandstone
Width
4.0 cm
Height
4.4 cm
Depth
3.4 cm

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