INTRODUCING OUR  HOLIDAY BUSINESS BUNDLE
LEARN MORE

<div id="cookie_notice" class="sw-cookie-notice sw--padding-vert-4 sw--padding-hor-1 sw-dms--box-shadow--big"> <div class="sw-dms--color-white sw-grid-flex sw-grid-flex--wrap-mob sw-grid-flex--wrap--tab"> <div class="sw-cookie-notice__text--mob sw--padding-left-8 sw--font-size-14 sw-grid-flex__cell-5-7 sw-grid-flex__cell-1-1--mob sw-grid-flex__cell-1-1--tab"> We use cookies to offer you a better browsing experience, including personalized advertising. By continuing to use the site you agree to their use. <a href="/legal/privacy-statement" target="_blank">Learn more</a> </div> <div class="sw-grid-flex__cell-2-7 sw-grid-flex__cell-1-1--mob sw-grid-flex__cell-1-1--tab"> <a class="sw-dms-button noty_close sw--padding-hor-7 sw--position-absolute sw--position-right sw--margin-right-13 sw--hide-mobile sw--hide-tablet" data-sw-set-cookie="euCookie">OK</a> <a class="sw-cookie-notice__btn--mob sw-cookie-notice__btn--tab sw-dms-button noty_close sw--padding-hor-7 sw--margin-vert-3 sw--hide-desktop" data-sw-set-cookie="euCookie">OK</a> </div> </div> </div>

<div class="sw--display-block sw-dms--color-white" style="background-color: #1e2740"> <div id="emailModalContentContainer"> <span class="noty_close sw--position-absolute sw--position-right sw--padding-top-3 sw--padding-right-3 icon-cancel sw--opacity-8 sw--z-index-10"></span> <div class="sw-row"> <div class="sw--position-relative sw--display-block sw--padding-3" style="min-width: 380px"> <p class="sw--font-size-16 sw--margin-bottom-2 sw--margin-right-6">Sign up to hear about special promotions</p> <form action="/register/email-signup" class="sw--position-relative" data-confirmation="emailConfirmationModal" data-sw-email-modal-form> <input type="text" class="sw--input-height__medium" style="width:60%;" placeholder="Email address" name="email" /> <input type="hidden" class="" name="location" value="/product/XWSDZB5WN/myc-max-recognizing-dna" /> <input type="hidden" class="" name="confirmation" value="emailConfirmationModal" /> <input type="submit" class="btn-primary sw--margin-left-1" value="Subscribe" /> <div id="emailModalFormError" class="text-error" style="display:none"></div> </form> </div> </div> </div>

Myc-Max recognizing DNA 3d printed Picture still generating

DIGITAL PREVIEW
Not a Photo

Picture still generating
Myc-Max recognizing DNA 3d printed Picture still generating
Myc-Max recognizing DNA 3d printed Picture still generating

DIGITAL PREVIEW
Not a Photo

Myc-Max recognizing DNA

Made by
Not For Sale
Product Description
PDB ID: 1NKP

X-ray structures of the basic/helix-loop-helix/leucine zipper (bHLHZ) domains of Myc-Max and Mad-Max heterodimers bound to their common DNA target (Enhancer or E box hexanucleotide, 5'-CACGTG-3') have been determined at 1.9 A and 2.0 A resolution, respectively. E box recognition by these two structurally similar transcription factor pairs determines whether a cell will divide and proliferate (Myc-Max) or differentiate and become quiescent (Mad-Max). Deregulation of Myc has been implicated in the development of many human cancers, including Burkitt's lymphoma, neuroblastomas, and small cell lung cancers. Both quasisymmetric heterodimers resemble the symmetric Max homodimer, albeit with marked structural differences in the coiled-coil leucine zipper regions that explain preferential homo- and heteromeric dimerization of these three evolutionarily related DNA-binding proteins. The Myc-Max heterodimer, but not its Mad-Max counterpart, dimerizes to form a bivalent heterotetramer, which explains how Myc can upregulate expression of genes with promoters bearing widely separated E boxes. 
 
Details
Sign In or Join to comment.
 
 
Logo

Hello.

We're sorry to inform you that we no longer support this browser and can't confirm that everything will work as expected. For the best Shapeways experience, please use one of the following browsers:

Click anywhere outside this window to continue.