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RSV Fusion Glycoprotein Prefusion 3d printed

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Glossy Full Color Sandstone
RSV Fusion Glycoprotein Prefusion 3d printed
RSV Fusion Glycoprotein Prefusion 3d printed

DIGITAL PREVIEW
Not a Photo

RSV Fusion Glycoprotein Prefusion

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$38.57
3D printed in fully colored material with a glossy and smooth finish.
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Product Description
Model Description
This 3D printed protein model of RSV Fusion Glycoprotein colored shades of magenta to visualize the viral binding protein's three fusion (F) chains. One chain is colored as a blue to red from N to C Terminal. This model was created from PDB ID:  
3RRR and paired with RSV Fusion Glycoprotein Postfusion 3D printed protein model. 
Protein Description
Bovine respiratory syncytial virus, a major cause of respiratory disease in calves, is closely related to human RSV, a leading cause of respiratory disease in infants. Recently, promising human RSV-vaccine candidates have been engineered that stabilize the metastable fusion (F) glycoprotein in its prefusion state; however, the absence of a relevant animal model for human RSV has complicated assessment of these vaccine candidates. Here, we use a combination of structure-based design, antigenic characterization, and X-ray crystallography to translate human RSV F stabilization into the bovine context. A "DS2" version of bovine respiratory syncytial virus F with subunits covalently fused, fusion peptide removed, and pre-fusion conformation stabilized by cavity-filling mutations and intra- and inter-protomer disulfides was recognized by pre-fusion-specific antibodies, AM14, D25, and MPE8, and elicited bovine respiratory syncytial virus-neutralizing titers in calves >100-fold higher than those elicited by post-fusion F. When challenged with a heterologous bovine respiratory syncytial virus, virus was not detected in nasal secretions nor in respiratory tract samples of DS2-immunized calves; by contrast bovine respiratory syncytial virus was detected in all post-fusion- and placebo-immunized calves. Our results demonstrate proof-of-concept that DS2-stabilized RSV F immunogens can induce highly protective immunity from RSV in a native host with implications for the efficacy of prefusion-stabilized F vaccines in humans and for the prevention of bovine respiratory syncytial virus in calves.
https://www.rcsb.org/structure/5tdl
Details
What's in the box:
Sml_prefusion_5tdl_beta_dot13_ml_VE12_x33
Dimensions:
2.96 x 2.97 x 2.96 cm
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1.17 x 1.17 x 1.17 inches
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Rating:
Mature audiences only.
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