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Ribonucleoprotein of Influenza Virus 3d printed

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Full Color Sandstone
 Ribonucleoprotein of Influenza Virus  3d printed
 Ribonucleoprotein of Influenza Virus  3d printed

DIGITAL PREVIEW
Not a Photo

Ribonucleoprotein of Influenza Virus

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OVERVIEW
  • 3D printed in Full Color Sandstone: Fully colored material with a coarse finish and a delicate feel.
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  • This product is intended for mature audiences.
$20.00
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Product Description

The influenza viruses contain a segmented, single-stranded RNA genome of negative polarity. Each RNA segment is encapsidated by the nucleoprotein and the polymerase complex into ribonucleoprotein particles (RNPs), which are responsible for virus transcription and replication. Despite their importance, information about the structure of these RNPs is scarce. We have determined the three-dimensional structure of a biologically active recombinant RNP by cryo-electron microscopy. The structure shows a nonameric nucleoprotein ring (at 12 Angstrom resolution) with two monomers connected to the polymerase complex (at 18 Angstrom resolution). Docking the atomic structures of the nucleoprotein and polymerase domains, as well as mutational analyses, has allowed us to define the interactions between the functional elements of the RNP and to propose the location of the viral RNA. Our results provide the first model for a functional negative-stranded RNA virus ribonucleoprotein complex. The structure reported here will serve as a framework to generate a quasi-atomic model of the molecular machine responsible for viral RNA synthesis and to test new models for virus RNA replication and transcription.

 
What's in the Box
INCM
EMDB-1603-surf-radial
Full Color Sandstone
Width
4.9 cm
Height
5.0 cm
Depth
1.8 cm

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