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[u]CCR5[/u]: C-C chemokine receptor type 5 (CCR5) is found on the surface of white blood cells. The CCR5 protein is part of the beta chemokine receptor family of integral membrane proteins. It is a G-protein-coupled receptor. It functions as a receptor for inflammatory CC chemokines and as a result, transduces a signal increasing the intracellular calcium ion level. It is most commonly known for its role as a coreceptor of human immunodeficiency virus-1 (HIV-1). HIV-1 uses chemokine receptors such as CCR5 as coreceptors to enter immune cells due to their location on the surface of the host cell’s, which provide HIV a method of entry. HIV-1 envelope glycoprotein structure facilitates viral entry into the host cells. The envelope protein mimics a chemokine giving HIV-1 the capability to bind to chemokine receptors. Knowledge of the mechanism by which HIV-1 interacts with CCR5 to cause infection has led scientists to attempt to develop therapeutic interventions to block CCR5 function. This class of HIV drugs is known as CCR5 receptor antagonists and interfere with the interaction between the envelope of HIV-1 and CCR5. These drugs are experimental and only one, Maraviroc, has been approved by the FDA for clinical use.