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Glp-1 1DOR 3d printed

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Glossy Full Color Sandstone
Glp-1 1DOR 3d printed
Glp-1 1DOR 3d printed

DIGITAL PREVIEW
Not a Photo

Glp-1 1DOR

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Product Description
3D Print of GLP-1 in full-color Sandstone created from PDB ID: 1DOR. 
Model Description
This is a 3D print of GLP-1. GLP-1 is colored blue and its active binding site yellow. In grey is the residue (already removed) clipped off by DPP-4, GLP-1 natural inhibitor.  Protein model designed to be used with 3D printed protein model of GLP-1 Receptor to demonstrate GLP-1 binding.

Protein Description
GLP-1 (glucagon-like peptide-1) is an incretin released from intestinal L-cells in response to food intake. Activation of the GLP-1 receptor potentiates the synthesis and release of insulin from pancreatic beta-cells in a glucose-dependent manner. The GLP-1 receptor belongs to class B of the G-protein-coupled receptors, a subfamily characterized by a large N-terminal extracellular ligand binding domain. Exendin-4 and GLP-1 are 50% identical, and exendin-4 is a full agonist with similar affinity and potency for the GLP-1 receptor. We recently solved the crystal structure of the GLP-1 receptor extracellular domain in complex with the competitive antagonist exendin-4(9-39). Interestingly, the isolated extracellular domain binds exendin-4 with much higher affinity than the endogenous agonist GLP-1. Here, we have solved the crystal structure of the extracellular domain in complex with GLP-1 to 2.1 Aresolution. The structure shows that important hydrophobic ligand-receptor interactions are conserved in agonist- and antagonist-bound forms of the extracellular domain, but certain residues in the ligand-binding site adopt a GLP-1-specific conformation. GLP-1 is a kinked but continuous alpha-helix from Thr(13) to Val(33) when bound to the extracellular domain. We supplemented the crystal structure with site-directed mutagenesis to link the structural information of the isolated extracellular domain with the binding properties of the full-length receptor. The data support the existence of differences in the binding modes of GLP-1 and exendin-4 on the full-length GLP-1 receptor. 
 
Details
What's in the box:
Glp 1
Dimensions:
2.65 x 3.84 x 2.39 cm
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1.04 x 1.51 x 0.94 inches
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Rating:
Mature audiences only.
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