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Human CaMKII-alpha hub 3d printed

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Human CaMKII-alpha hub 3d printed
Human CaMKII-alpha hub 3d printed

DIGITAL PREVIEW
Not a Photo

Human CaMKII-alpha hub

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Product Description

Activation triggers the exchange of subunits in Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), an oligomeric enzyme that is critical for learning, memory, and cardiac function. The mechanism by which subunit exchange occurs remains elusive. We show that the human CaMKII holoenzyme exists in dodecameric and tetradecameric forms, and that the calmodulin(CaM)-binding element of CaMKII can bind to the hub of the holoenzyme and destabilize it to release dimers. The structures of CaMKII from two distantly diverged organisms suggest that the CaM-binding element of activated CaMKII acts as a wedge by docking at intersubunit interfaces in the hub. This converts the hub into a spiral form that can release or gain CaMKII dimers. Our data reveal a three-way competition for the CaM-binding element, whereby phosphorylation biases it towards the hub interface, away from the kinase domain and calmodulin, thus unlocking the ability of activated CaMKII holoenzymes to exchange dimers with unactivated ones. 
 
What's in the Box
INCM
Sml: CaMKII
Coated Full Color Sandstone
Width
8.4 cm
Height
8.6 cm
Depth
2.9 cm
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