SHAPEWAYS    STRATASYS FULL COLOR, MULTI MATERIAL! LEARN MORE LEARN MORE

<div id="cookie_notice" class="sw-cookie-notice sw--padding-vert-4 sw--padding-hor-1 sw-dms--box-shadow--big"> <div class="sw-dms--color-white sw-grid-flex sw-grid-flex--wrap-mob sw-grid-flex--wrap--tab"> <div class="sw-cookie-notice__text--mob sw--padding-left-8 sw--font-size-14 sw-grid-flex__cell-5-7 sw-grid-flex__cell-1-1--mob sw-grid-flex__cell-1-1--tab"> We use cookies to offer you a better browsing experience, including personalized advertising. By continuing to use the site you agree to their use. <a href="/legal/privacy-statement" target="_blank">Learn more</a> </div> <div class="sw-grid-flex__cell-2-7 sw-grid-flex__cell-1-1--mob sw-grid-flex__cell-1-1--tab"> <a class="sw-dms-button noty_close sw--padding-hor-7 sw--position-absolute sw--position-right sw--margin-right-13 sw--hide-mobile sw--hide-tablet" data-sw-set-cookie="euCookie">OK</a> <a class="sw-cookie-notice__btn--mob sw-cookie-notice__btn--tab sw-dms-button noty_close sw--padding-hor-7 sw--margin-vert-3 sw--hide-desktop" data-sw-set-cookie="euCookie">OK</a> </div> </div> </div>

Click and drag to rotate
Niemann Pick C1 Volumetric Surface 3d printed

DIGITAL PREVIEW
Not a Photo

Glossy Full Color Sandstone
Niemann Pick C1 Volumetric Surface 3d printed
Niemann Pick C1 Volumetric Surface 3d printed

DIGITAL PREVIEW
Not a Photo

Niemann Pick C1 Volumetric Surface

Made by
$57.68
3D printed in fully colored material with a glossy and smooth finish.
QTY
Product Description
Niemann-Pick C1 protein (NPC1) is a late-endosomal membrane protein involved in trafficking of LDL-derived cholesterol, Niemann-Pick disease type C, and Ebola virus infection. NPC1 contains 13 transmembrane segments (TMs), five of which are thought to represent a "sterol-sensing domain" (SSD). Although present also in other key regulatory proteins of cholesterol biosynthesis, uptake, and signaling, the structure and mechanism of action of the SSD are unknown. Here we report a crystal structure of a large fragment of human NPC1 at 3.6 Å resolution, which reveals internal twofold pseudosymmetry along TM 2-13 and two structurally homologous domains that protrude 60 Å into the endosomal lumen. Strikingly, NPC1's SSD forms a cavity that is accessible from both the luminal bilayer leaflet and the endosomal lumen; computational modeling suggests that this cavity is large enough to accommodate one cholesterol molecule. We propose a model for NPC1 function in cholesterol sensing and transport.
Details
What's in the box:
Niemann Pick C1 Surf V4 Ml
Dimensions:
4.32 x 8.33 x 4.45 cm
Switch to inches
1.7 x 3.28 x 1.75 inches
Switch to cm
Success Rate:
First To try.
What's this?
Rating:
Mature audiences only.
Sign In or Join to comment.
 
 
Logo

Hello.

We're sorry to inform you that we no longer support this browser and can't confirm that everything will work as expected. For the best Shapeways experience, please use one of the following browsers:

Click anywhere outside this window to continue.