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HIV Glycan Shield 3d printed

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Natural Full Color Sandstone
HIV Glycan Shield 3d printed
HIV Glycan Shield 3d printed

DIGITAL PREVIEW
Not a Photo

HIV Glycan Shield

Made by
$50.00
3D printed in fully colored material with a coarse finish and a delicate feel.
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Product Description
The HIV-1-envelope (Env) trimer is covered by a glycan shield of 90 N-linked oligosaccharides, which comprises roughly half its mass and is a key component of HIV evasion from humoral immunity. To understand how antibodies can overcome the barriers imposed by the glycan shield, we crystallized fully glycosylated Env trimers from clades A, B, and G, visualizing the shield at 3.4-3.7 Å resolution. These structures reveal the HIV-1-glycan shield to comprise a network of interlocking oligosaccharides, substantially ordered by glycan crowding, that encase the protein component of Env and enable HIV-1 to avoid most antibody-mediated neutralization. The revealed features delineate a taxonomy of N-linked glycan-glycan interactions. Crowded and dispersed glycans are differently ordered, conserved, processed, and recognized by antibody. The structures, along with glycan-array binding and molecular dynamics, reveal a diversity in oligosaccharide affinity and a requirement for accommodating glycans among known broadly neutralizing antibodies that target the glycan-shielded trimer.
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Details
What's in the box:
HIV Trimer Protein
Dimensions:
6.51 x 6.11 x 5.74 cm
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2.56 x 2.41 x 2.26 inches
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Success Rate:
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Rating:
Mature audiences only.
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