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CRISPR-Cpf1 5B43 3d printed

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Glossy Full Color Sandstone
CRISPR-Cpf1 5B43 3d printed
CRISPR-Cpf1 5B43 3d printed

DIGITAL PREVIEW
Not a Photo

CRISPR-Cpf1 5B43

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$46.01
Ships as soon as 14 days
3D printed in fully colored material with a glossy and smooth finish.
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Product Description
Cpf1 is an RNA-guided endonuclease of a type V CRISPR-Cas system that has been recently harnessed for genome editing. Here, we report the crystal structure of Acidaminococcus sp. Cpf1 (AsCpf1) in complex with the guide RNA and its target DNA at 2.8 Å resolution. AsCpf1 adopts a bilobed architecture, with the RNA-DNA heteroduplex bound inside the central channel. The structural comparison of AsCpf1 with Cas9, a type II CRISPR-Cas nuclease, reveals both striking similarity and major differences, thereby explaining their distinct functionalities. AsCpf1 contains the RuvC domain and a putative novel nuclease domain, which are responsible for cleaving the non-target and target strands, respectively, and for jointly generating staggered DNA double-strand breaks. AsCpf1 recognizes the 5'-TTTN-3' protospacer adjacent motif by base and shape readout mechanisms. Our findings provide mechanistic insights into RNA-guided DNA cleavage by Cpf1 and establish a framework for rational engineering of the CRISPR-Cpf1 toolbox.
Details
What's in the box:
exsml_CRISPR_Cpf1_ml_vC6_x40
Dimensions:
3.2 x 4.92 x 3.4 cm
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1.26 x 1.94 x 1.34 inches
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Success Rate:
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Rating:
Mature audiences only.
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