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CRISPR-Cas9 in complex with sgRNA and target DNA 3d printed

Not a Photo

Coated Full Color Sandstone
CRISPR-Cas9 in complex with sgRNA and target DNA  3d printed
CRISPR-Cas9 in complex with sgRNA and target DNA  3d printed

Not a Photo

CRISPR-Cas9 in complex with sgRNA and target DNA

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3D printed in fully colored material with a glossy and smooth finish.
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Product Description
Protein Descrption
"The RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA targets with a protospacer adjacent motif (PAM) and complementarity to the guide RNA. Recently, we harnessed Staphylococcus aureus Cas9 (SaCas9), which is significantly smaller than Streptococcus pyogenes Cas9 (SpCas9), to facilitate efficient in vivo genome editing. Here, we report the crystal structures of SaCas9 in complex with a single guide RNA (sgRNA) and its double-stranded DNA targets, containing the 5'-TTGAAT-3' PAM and the 5'-TTGGGT-3' PAM, at 2.6 and 2.7 Å resolutions, respectively. The structures revealed the mechanism of the relaxed recognition of the 5'-NNGRRT-3' PAM by SaCas9. A structural comparison of SaCas9 with SpCas9 highlighted both structural conservation and divergence, explaining their distinct PAM specificities and orthologous sgRNA recognition. Finally, we applied the structural information about this minimal Cas9 to rationally design compact transcriptional activators and inducible nucleases, to further expand the CRISPR-Cas9 genome editing toolbox."


Model Description
CRISPR-Cas9 printed in full-color sandstone colored purple according to the protein's bFactor, it's propensity for movement. RNA is colored red, DNA colored Yellow and Green. 
What's in the box:
ExSml: CRISPR Cas9
3.5 x 4.73 x 3.12 cm
Switch to inches
1.38 x 1.86 x 1.23 inches
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Success Rate:
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Mature audiences only.
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