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Chemokine Receptor 3d printed

DIGITAL PREVIEW
Not a Photo

Glossy Full Color Sandstone
Chemokine Receptor 3d printed
Chemokine Receptor 3d printed

DIGITAL PREVIEW
Not a Photo

Chemokine Receptor

Made by
$60.00
3D printed in fully colored material with a glossy and smooth finish.
QTY
Product Description
Chemokine receptors are critical regulators of cell migration in the context of immune surveillance, inflammation, and development. The G protein-coupled chemokine receptor CXCR4 is specifically implicated in cancer metastasis and HIV-1 infection. Here we report five independent crystal structures of CXCR4 bound to an antagonist small molecule IT1t and a cyclic peptide CVX15 at 2.5 to 3.2 angstrom resolution. All structures reveal a consistent homodimer with an interface including helices V and VI that may be involved in regulating signaling. The location and shape of the ligand-binding sites differ from other G protein-coupled receptors and are closer to the extracellular surface. These structures provide new clues about the interactions between CXCR4 and its natural ligand CXCL12, and with the HIV-1 glycoprotein gp120.
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Details
What's in the box:
Chemokine Receptor
Dimensions:
8.07 x 10.29 x 9.55 cm
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3.18 x 4.05 x 3.76 inches
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Success Rate:
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Rating:
Mature audiences only.
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