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GLP-1 Analog in Complex with GLP-1 Receptor 3d printed

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Coated Full Color Sandstone
GLP-1 Analog in Complex with GLP-1 Receptor 3d printed
GLP-1 Analog in Complex with GLP-1 Receptor 3d printed

DIGITAL PREVIEW
Not a Photo

GLP-1 Analog in Complex with GLP-1 Receptor

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  • 3D printed in Coated Full Color Sandstone: Fully colored material with a glossy and smooth finish.
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  • This product is intended for mature audiences.
$36.76
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Product Description

This is a 3D print of GLP-1 Analog in Complex with GLP-1 Receptor.

 

Liraglutide is an acylated glucagon-like peptide-1 (GLP-1) analogue that binds to serum albumin in vivo and is approved for once-daily treatment of diabetes as well as obesity. The aim of the present studies was to design a once weekly GLP-1 analogue by increasing albumin affinity and secure full stability against metabolic degradation. The fatty acid moiety and the linking chemistry to GLP-1 were the key features to secure high albumin affinity and GLP-1 receptor (GLP-1R) potency and in obtaining a prolonged exposure and action of the GLP-1 analogue. Semaglutide was selected as the optimal once weekly candidate. Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib(8), Arg(34)) and is derivatized at lysine 26. The GLP-1R affinity of semaglutide (0.38 ± 0.06 nM) was three-fold decreased compared to liraglutide, whereas the albumin affinity was increased. The plasma half-life was 46.1 h in mini-pigs following i.v. administration, and semaglutide has an MRT of 63.6 h after s.c. dosing to mini-pigs. Semaglutide is currently in phase 3 clinical testing. 
 

      
What's in the Box
INCM
GLP-1 Analog in Complex with GLP-1 Receptor
Coated Full Color Sandstone
Width
4.0 cm
Height
6.6 cm
Depth
3.6 cm

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