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Chromobox Homolog 8 (CBX8) with H3K9 peptide 3d printed

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Glossy Full Color Sandstone
Chromobox Homolog 8 (CBX8) with H3K9 peptide 3d printed
Chromobox Homolog 8 (CBX8) with H3K9 peptide 3d printed

DIGITAL PREVIEW
Not a Photo

Chromobox Homolog 8 (CBX8) with H3K9 peptide

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$124.35
Ships as soon as 15 days
3D printed in fully colored material with a glossy and smooth finish.
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Product Description
The eight mammalian Cbx proteins are chromodomain-containing proteins involved in regulation of heterochromatin, gene expression, and developmental programs. They are evolutionarily related to the Drosophila HP1 (dHP1) and Pc (dPc) proteins that are key components of chromatin-associated complexes capable of recognizing repressive marks such as trimethylated Lys-9 and Lys-27, respectively, on histone H3. However, the binding specificity and function of the human homologs, Cbx1-8, remain unclear. To this end we employed structural, biophysical, and mutagenic approaches to characterize the molecular determinants of sequence contextual methyllysine binding to human Cbx1-8 proteins. Although all three human HP1 homologs (Cbx1, -3, -5) replicate the structural and binding features of their dHP counterparts, the five Pc homologs (Cbx2, -4, -6, -7, -8) bind with lower affinity to H3K9me3 or H3K27me3 peptides and are unable to distinguish between these two marks. Additionally, peptide permutation arrays revealed a greater sequence tolerance within the Pc family and suggest alternative nonhistone sequences as potential binding targets for this class of chromodomains. Our structures explain the divergence of peptide binding selectivity in the Pc subfamily and highlight previously unrecognized features of the chromodomain that influence binding and specificity.
Details
What's in the box:
CBX8_3i91_chi_v2
Dimensions:
8.04 x 6.49 x 6.59 cm
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3.16 x 2.55 x 2.59 inches
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Success Rate:
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Rating:
Mature audiences only.
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