Click and drag to rotate
Superhelix Model of High Density Lipoprotein 3K2S 3d printed

DIGITAL PREVIEW
Not a Photo

Glossy Full Color Sandstone
Superhelix Model of High Density Lipoprotein 3K2S 3d printed
Superhelix Model of High Density Lipoprotein 3K2S 3d printed

DIGITAL PREVIEW
Not a Photo

Superhelix Model of High Density Lipoprotein 3K2S

Made by
$44.89
Ships as soon as 15 days
3D printed in fully colored material with a glossy and smooth finish.
QTY

Have a question about this product?

contact the designer
You must be logged in and verified to contact the designer.
Product Description
High density lipoprotein (HDL), the carrier of so-called "good" cholesterol, serves as the major athero-protective lipoprotein and has emerged as a key therapeutic target for cardiovascular disease. We applied small angle neutron scattering (SANS) with contrast variation and selective isotopic deuteration to the study of nascent HDL to obtain the low resolution structure in solution of the overall time-averaged conformation of apolipoprotein AI (apoA-I) versus the lipid (acyl chain) core of the particle. Remarkably, apoA-I is observed to possess an open helical shape that wraps around a central ellipsoidal lipid phase. Using the low resolution SANS shapes of the protein and lipid core as scaffolding, an all-atom computational model for the protein and lipid components of nascent HDL was developed by integrating complementary structural data from hydrogen/deuterium exchange mass spectrometry and previously published constraints from multiple biophysical techniques. Both SANS data and the new computational model, the double superhelix model, suggest an unexpected structural arrangement of protein and lipids of nascent HDL, an anti-parallel double superhelix wrapped around an ellipsoidal lipid phase. The protein and lipid organization in nascent HDL envisages a potential generalized mechanism for lipoprotein biogenesis and remodeling, biological processes critical to sterol and lipid transport, organismal energy metabolism, and innate immunity.
Tags
3K2S HDL
Details
What's in the box:
exsml_HDL_3K2S_ml_vD9_x32d5
Dimensions:
3.14 x 5.54 x 2.53 cm
Switch to inches
1.24 x 2.18 x 0.99 inches
Switch to cm
Success Rate:
First To try.
What's this?
Rating:
Mature audiences only.
Logo

Hello.

We're sorry to inform you that we no longer support this browser and can't confirm that everything will work as expected. For the best Shapeways experience, please use one of the following browsers:

Click anywhere outside this window to continue.