Click and drag to rotate
HER2 Tyrosine Kinase 3RCD 3d printed

Not a Photo

Glossy Full Color Sandstone
HER2 Tyrosine Kinase 3RCD 3d printed
HER2 Tyrosine Kinase 3RCD 3d printed

Not a Photo

HER2 Tyrosine Kinase 3RCD

Made by
3D printed in fully colored material with a glossy and smooth finish.

Have a question about this product?

contact the designer
You must be logged in and verified to contact the designer.
Product Description
Dual inhibitors of human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR) have been investigated for breast, lung, gastric, prostate, and other cancers; one, lapatinib, is currently approved for breast cancer. To develop novel HER2/EGFR dual kinase inhibitors, we designed and synthesized pyrrolo[3,2-d]pyrimidine derivatives capable of fitting into the receptors' ATP binding site. Among the prepared compounds, 34e showed potent HER2 and EGFR (HER1) inhibitory activities as well as tumor growth inhibitory activity. The X-ray cocrystal structures of 34e with both HER2 and EGFR demonstrated that 34e interacts with the expected residues in their respective ATP pockets. Furthermore, reflecting its good oral bioavailability, 34e exhibited potent in vivo efficacy in HER2-overexpressing tumor xenograft models. On the basis of these findings, we report 34e (TAK-285) as a promising candidate for clinical development as a novel HER2/EGFR dual kinase inhibitor.​ 
What's in the box:
Lrg: her2_3poz_aloop_4hjo
10.91 x 12.15 x 8.19 cm
Switch to inches
4.3 x 4.78 x 3.22 inches
Switch to cm
Success Rate:
First To try.
What's this?
Mature audiences only.


We're sorry to inform you that we no longer support this browser and can't confirm that everything will work as expected. For the best Shapeways experience, please use one of the following browsers:

Click anywhere outside this window to continue.