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Mus81-Eme1-3'flap DNA Complex 3d printed

DIGITAL PREVIEW
Not a Photo

Coated Full Color Sandstone
Mus81-Eme1-3'flap DNA Complex 3d printed
Mus81-Eme1-3'flap DNA Complex 3d printed

DIGITAL PREVIEW
Not a Photo

Mus81-Eme1-3'flap DNA Complex

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Size
OVERVIEW
  • 3D printed in Coated Full Color Sandstone: Fully colored material with a glossy and smooth finish.
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  • This product is intended for mature audiences.
$30.99
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Product Description

Model Description
This is a full-color sandstone 3d print of Mus81 DNA Complex made from PDB ID: 
4P0R.

Protein Description
The Mus81-Eme1 complex is a structure-selective endonuclease with a critical role in the resolution of recombination intermediates during DNA repair after interstrand cross-links, replication fork collapse, or double-strand breaks. To explain the molecular basis of 3' flap substrate recognition and cleavage mechanism by Mus81-Eme1, we determined crystal structures of human Mus81-Eme1 bound to various flap DNA substrates. Mus81-Eme1 undergoes gross substrate-induced conformational changes that reveal two key features: (i) a hydrophobic wedge of Mus81 that separates pre- and post-nick duplex DNA and (ii) a "5' end binding pocket" that hosts the 5' nicked end of post-nick DNA. These features are crucial for comprehensive protein-DNA interaction, sharp bending of the 3' flap DNA substrate, and incision strand placement at the active site. While Mus81-Eme1 unexpectedly shares several common features with members of the 5' flap nuclease family, the combined structural, biochemical, and biophysical analyses explain why Mus81-Eme1 preferentially cleaves 3' flap DNA substrates with 5' nicked ends. 

http://www.rcsb.org/pdb/explore.do?structureId=4p0r
What's in the Box
INCM
Mus81 4cm
Coated Full Color Sandstone
Width
4.1 cm
Height
4.6 cm
Depth
2.8 cm
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