<div id="cookie_notice" class="sw-row sw--padding-2 sw--padding-bottom-1-force sw--text-center sw--bg-grey" > <div class="col-1-2 col-1-1--tab col--no-padding sw--display-inline-block sw--float-none sw--text-left sw--vertical-align__middle"> <p class="col-1-2 col--no-padding small">We use cookies to offer you a better browsing experience. By continuing to use the site you agree to their use. You can find out more about our cookies and read our privacy policy <a href="/legal/privacy-statement" target="_blank">here.</a></p> <div class="col-1-2 col--no-padding sw--text-center"> <div class="col-1-2 col--no-padding sw--display-inline-block sw--float-none"> <a class="btn-white small noty_close col-1-1 col--no-padding" data-sw-set-cookie="euCookie">OK</a> </div> </div> </div> </div>

<div class="sw--display-block sw--text-white sw--bg-dark-gray"> <div id="emailModalContentContainer"> <span class="noty_close sw--position-absolute sw--position-right sw--padding-top-3 sw--padding-right-3 icon-cancel sw--opacity-8 sw--z-index-10"></span> <div class="sw-row"> <div class="sw--position-relative sw--display-block sw--padding-3"> <p class="sw--font-size-16 sw--margin-bottom-2 sw--margin-right-6">Sign up to hear about special promotions</p> <form action="/register/email-signup" class="sw--position-relative" data-confirmation="emailConfirmationModal" data-sw-email-modal-form> <input type="text" class="sw--input-height__medium" style="width:60%;" placeholder="Email address" name="email" /> <input type="hidden" class="" name="location" value="/product/9ZGV2U4SZ/mus81-eme1-3-flap-dna-complex" /> <input type="hidden" class="" name="confirmation" value="emailConfirmationModal" /> <input type="submit" class="btn-primary sw--margin-left-1" value="Subscribe" /> <div id="emailModalFormError" class="text-error" style="display:none"></div> </form> </div> </div> </div>

Click and drag to rotate
Mus81-Eme1-3'flap DNA Complex 3d printed

DIGITAL PREVIEW
Not a Photo

Glossy Full Color Sandstone
Mus81-Eme1-3'flap DNA Complex 3d printed
Mus81-Eme1-3'flap DNA Complex 3d printed

DIGITAL PREVIEW
Not a Photo

Mus81-Eme1-3'flap DNA Complex

Made by
$30.99
3D printed in fully colored material with a glossy and smooth finish.
QTY
All orders are backed by our
All orders are backed by our
Money Back Guarantee.
Product Description
Model Description
This is a full-color sandstone 3d print of Mus81 DNA Complex made from PDB ID: 
4P0R.

Protein Description
The Mus81-Eme1 complex is a structure-selective endonuclease with a critical role in the resolution of recombination intermediates during DNA repair after interstrand cross-links, replication fork collapse, or double-strand breaks. To explain the molecular basis of 3' flap substrate recognition and cleavage mechanism by Mus81-Eme1, we determined crystal structures of human Mus81-Eme1 bound to various flap DNA substrates. Mus81-Eme1 undergoes gross substrate-induced conformational changes that reveal two key features: (i) a hydrophobic wedge of Mus81 that separates pre- and post-nick duplex DNA and (ii) a "5' end binding pocket" that hosts the 5' nicked end of post-nick DNA. These features are crucial for comprehensive protein-DNA interaction, sharp bending of the 3' flap DNA substrate, and incision strand placement at the active site. While Mus81-Eme1 unexpectedly shares several common features with members of the 5' flap nuclease family, the combined structural, biochemical, and biophysical analyses explain why Mus81-Eme1 preferentially cleaves 3' flap DNA substrates with 5' nicked ends. 

http://www.rcsb.org/pdb/explore.do?structureId=4p0r
Details
What's in the box:
Mus81 4cm
Dimensions:
4.14 x 4.56 x 2.82 cm
Switch to inches
1.63 x 1.8 x 1.11 inches
Switch to cm
Success Rate:
First To try.
What's this?
Rating:
Mature audiences only.
Sign In or Join to comment.
 
 
Logo

Hello.

We're sorry to inform you that we no longer support this browser and can't confirm that everything will work as expected. For the best Shapeways experience, please use one of the following browsers:

Click anywhere outside this window to continue.