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Niemann Pick C1 3d printed

DIGITAL PREVIEW
Not a Photo

Coated Full Color Sandstone
Niemann Pick C1 3d printed
Niemann Pick C1 3d printed

DIGITAL PREVIEW
Not a Photo

Niemann Pick C1

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  • 3D printed in Coated Full Color Sandstone: Fully colored material with a glossy and smooth finish.
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  • This product is intended for mature audiences.
$76.66
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Product Description

Niemann-Pick C1 protein (NPC1) is a late-endosomal membrane protein involved in trafficking of LDL-derived cholesterol, Niemann-Pick disease type C, and Ebola virus infection. NPC1 contains 13 transmembrane segments (TMs), five of which are thought to represent a "sterol-sensing domain" (SSD). Although present also in other key regulatory proteins of cholesterol biosynthesis, uptake, and signaling, the structure and mechanism of action of the SSD are unknown. Here we report a crystal structure of a large fragment of human NPC1 at 3.6 Å resolution, which reveals internal twofold pseudosymmetry along TM 2-13 and two structurally homologous domains that protrude 60 Å into the endosomal lumen. Strikingly, NPC1's SSD forms a cavity that is accessible from both the luminal bilayer leaflet and the endosomal lumen; computational modeling suggests that this cavity is large enough to accommodate one cholesterol molecule. We propose a model for NPC1 function in cholesterol sensing and transport. 
http://www.rcsb.org/pdb/explore.do?structureId=5i31
What's in the Box
INCM
Mdm: Niemann Pick C1
Coated Full Color Sandstone
Width
6.1 cm
Height
11.4 cm
Depth
6.5 cm
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