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Ebola Virus Ectodomain 3d printed

DIGITAL PREVIEW
Not a Photo

Coated Full Color Sandstone
Ebola Virus Ectodomain 3d printed
Ebola Virus Ectodomain 3d printed

DIGITAL PREVIEW
Not a Photo

Ebola Virus Ectodomain

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  • 3D printed in Coated Full Color Sandstone: Fully colored material with a glossy and smooth finish.
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  • This product is intended for mature audiences.
$65.53
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Product Description

Learn more about the Ebola Virus at Biologic Modelshttps://biologicmodels.com/project/ebola-virus-ectodomain/ Ebola virus (EBOV) entry requires the surface glycoprotein (GP) to initiate attachment and fusion of viral and host membranes. Here we report the crystal structure of EBOV GP in its trimeric, pre-fusion conformation (GP1+GP2) bound to a neutralizing antibody, KZ52, derived from a human survivor of the 1995 Kikwit outbreak. Three GP1 viral attachment subunits assemble to form a chalice, cradled by the GP2 fusion subunits, while a novel glycan cap and projected mucin-like domain restrict access to the conserved receptor-binding site sequestered in the chalice bowl. The glycocalyx surrounding GP is likely central to immune evasion and may explain why survivors have insignificant neutralizing antibody titres. KZ52 recognizes a protein epitope at the chalice base where it clamps several regions of the pre-fusion GP2 to the amino terminus of GP1. This structure provides a template for unravelling the mechanism of EBOV GP-mediated fusion and for future immunotherapeutic development.
What's in the Box
INCM
Sml: Ebola Virus Ectodomain
Coated Full Color Sandstone
Width
5.6 cm
Height
8.7 cm
Depth
6.0 cm

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