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T4 Phage SF1B Helicase in Complex with DNA 3d printed

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T4 Phage SF1B Helicase in Complex with DNA 3d printed
T4 Phage SF1B Helicase in Complex with DNA 3d printed

DIGITAL PREVIEW
Not a Photo

T4 Phage SF1B Helicase in Complex with DNA

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Product Description
Model Description
This 3D print displays the stabalizing residues of T4 Phage, including Phe98 and 276, as indicarted below. The Single-stranded DNA is displayed in Slab style.

 
Protein Description
"Helicases move on DNA via an ATP binding and hydrolysis mechanism coordinated by well-characterized helicase motifs. However, the translocation along single-stranded DNA (ssDNA) and the strand separation of double-stranded (dsDNA) may be loosely or tightly coupled. Dda is a phage T4 SF1B helicase with sequence homology to the Pif1 family of helicases that tightly couples translocation to strand separation.

 

The crystal structure of the Dda-ssDNA binary complex reveals a domain referred to as the "pin" that was previously thought to remain static during strand separation. The pin contains a conserved phenylalanine that mediates a transient base-stacking interaction that is absolutely required for separation of dsDNA. The pin is secured at its tip by protein-protein interactions through an extended SH3 domain thereby creating a rigid strut. The conserved interface between the pin and the SH3 domain provides the mechanism for tight coupling of translocation to strand separation. "

RCSB Link: http://www.rcsb.org/pdb/explore.do?structureId=3upu

            
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