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Human NatA 3d printed

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Glossy Full Color Sandstone
Human NatA 3d printed
Human NatA 3d printed

DIGITAL PREVIEW
Not a Photo

Human NatA

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$125.80
Ships as soon as 13 days
3D printed in fully colored material with a glossy and smooth finish.
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Product Description
3D printed protein model of Human  NatA  created from PDB ID: 6C95.
Model Description
This 3D printed protein model of Human NatA is visualized as a volumetric surface and colored to distinguish how multiple chains interact. Chain B is colored cyan and residue 100 in red. Chains A and C colored light and dark grey.
Protein Description
Co-translational N-terminal protein acetylation regulates many protein functions including degradation, folding, interprotein interactions, and targeting. Human NatA (hNatA), one of six conserved metazoan N-terminal acetyltransferases, contains Naa10 catalytic and Naa15 auxiliary subunits, and associates with the intrinsically disordered Huntingtin yeast two-hybrid protein K (HYPK). We report on the crystal structures of hNatA and hNatA/HYPK, and associated biochemical and enzymatic analyses. We demonstrate that hNatA contains unique features: a stabilizing inositol hexaphosphate (IP6) molecule and a metazoan-specific Naa15 domain that mediates high-affinity HYPK binding. We find that HYPK harbors intrinsic hNatA-specific inhibitory activity through a bipartite structure: a ubiquitin-associated domain that binds a hNaa15 metazoan-specific region and an N-terminal loop-helix region that distorts the hNaa10 active site. We show that HYPK binding blocks hNaa50 targeting to hNatA, likely limiting Naa50 ribosome localization in vivo. These studies provide a model for metazoan NAT activity and HYPK regulation of N-terminal acetylation.
Details
What's in the box:
mdm_human_natA_6C95_ml_v1_x83
Dimensions:
6.56 x 7.11 x 7.85 cm
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2.58 x 2.8 x 3.09 inches
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Rating:
Mature audiences only.
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