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The rhinovirus is the most common viral infectious agent in humans and is the predominant cause of the common cold. Rhinovirus infection proliferates in temperatures between 33–35 °C (91–95 °F), the temperatures found in the nose. Rhinoviruses is a genus within the Picornaviridae family of viruses. There are currently around 160 recognized types of human rhinoviruses that differ according to their surface proteins (serotypes). They are lytic in nature and are among the smallest viruses, with diameters of about 30 nanometers. By comparison, other viruses, such as smallpox and vaccinia, are around 10 times larger at about 300 nanometers; while flu viruses are around 80–120nm.