<div class="sw--display-block sw--text-white sw--bg-dark-gray"> <div id="emailModalContentContainer"> <span class="noty_close sw--position-absolute sw--position-right sw--padding-top-3 sw--padding-right-3 icon-cancel sw--opacity-8 sw--z-index-10"></span> <div class="sw-row"> <div class="sw--position-relative sw--display-block sw--padding-3"> <p class="sw--font-size-16 sw--margin-bottom-2 sw--margin-right-6">Sign up to hear about special promotions</p> <form action="/register/email-signup" class="sw--position-relative" data-confirmation="emailConfirmationModal" data-sw-email-modal-form> <input type="text" class="sw--input-height__medium" style="width:60%;" placeholder="Email address" name="email" /> <input type="hidden" class="" name="location" value="/product/2GQV4NEET/tumor-necrosis-factor-tnf" /> <input type="hidden" class="" name="confirmation" value="emailConfirmationModal" /> <input type="submit" class="btn-primary sw--margin-left-1" value="Subscribe" /> <div id="emailModalFormError" class="text-error" style="display:none"></div> </form> </div> </div> </div>

Click and drag to rotate
Tumor Necrosis Factor (TNF) 3d printed

Not a Photo

Full Color Sandstone
Tumor Necrosis Factor (TNF) 3d printed
Tumor Necrosis Factor (TNF) 3d printed

Not a Photo

Tumor Necrosis Factor (TNF)

Made by
3D printed in fully colored material with a coarse finish and a delicate feel.
All orders are backed by our
All orders are backed by our
Money Back Guarantee.
Product Description
The three-dimensional structure of tumor necrosis factor (TNF-alpha), a protein hormone secreted by macrophages, has been determined at 2.6 A resolution by x-ray crystallography. Phases were determined by multiple isomorphous replacement using data collected from five heavy atom derivatives. The multiple isomorphous replacement phases were further improved by real space symmetry averaging, exploiting the noncrystallographic 3-fold symmetry of the TNF-alpha trimer. An atomic model corresponding to the known amino acid sequence of TNF-alpha was readily built into the electron density map calculated with these improved phases. The 17,350-dalton monomer forms an elongated, antiparallel beta-pleated sheet sandwich with a "jelly-roll" topology. Three monomers associate intimately about a 3-fold axis of symmetry to form a compact bell-shaped trimer. Examination of the model and comparison to known protein structures reveals striking structural homology to several viral coat proteins, particularly satellite tobacco necrosis virus. Locations of residues conserved between TNF-alpha and lymphotoxin (TNF-beta, a related cytokine known to bind to the same receptors as TNF-alpha) suggest that lymphotoxin, like TNF-alpha, binds to the receptor as a trimer and that the general site of interaction with the receptor is at the "base" of the trimer.
What's in the box:
Tumor Necrosis Factor (TNF)
3.59 x 4.06 x 3.47 cm
Switch to inches
1.42 x 1.6 x 1.37 inches
Switch to cm
Success Rate:
First To try.
What's this?
Mature audiences only.
Sign In or Join to comment.


We're sorry to inform you that we no longer support this browser and can't confirm that everything will work as expected. For the best Shapeways experience, please use one of the following browsers:

Click anywhere outside this window to continue.