Feline Calicivirus bound to JAM 2M x magnification

Design by DavidBhella

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This is a three-dimensional reconstruction of Feline Calicivirus bound to its cellular receptor Junctional Adhesion Molecule A, solved by cryo-electron microscopy. It is therefore an exact scale model of the virus receptor complex (approximately 2,000,000 x). Receptor binding induces a conformational change in the capsid, this model shows the structure before the conformational change. This structure was reported in "The cryo-electron microscopy structure of feline calicivirus bound to junctional adhesion molecule A at 9-angstrom resolution reveals receptor-induced flexibility and two distinct conformational changes in the capsid protein VP1" Bhella D, Goodfellow IG. J Virol. 2011 Nov;85(21):11381-90

cm: 9.792 w x 9.824 d x 9.8 h

in: 3.855 w x 3.868 d x 3.858 h