Jrey's wife is from the Bahamas so he designed a sea shell ring and set of earrings to remind her of home and had them 3D printed in Sterling Silver by Shapeways. The jewelry looks beautiful and she absolutely loved them. Now this is the only jewelry of it's kind in the entire world, made especially for one woman designed for her alone by her husband. This is the kind of gift that will be passed on for generations, with the grandmother telling the granddaughter the story of it's creation, and the depth of meaning that far exceeds any item bought off of the shelf.
I agree completely - most of the things I've been doing have been for particular people. Some of them truly will be unique, because I won't ever put them up for sale. My dad stamps the bottom of his pottery with a stamp I made a year ago.
Though it takes much more time (and often more money), nothing really compares to the sentimental value of a personal gift.