Every now and then you see a new idea that you just KNOW is going to change things. Here's one by BMW Design: a shape-shifting car covered with fabric. The shape of the car (the GINA - 'Geometry and functions In 'N' Adaptions') can be changed by a system of electric and hydraulic actuators, allowing the driver to, say, the size of the spoiler or the fenders.
By stepping away from the existing design restrictions, BMW could suddenly achieve amazing new possibilities like the changing shape, but also the use of transparent material for the taillights. Similarly, when using 3D printing techniques you'll also find that you can cast off your existing design restrictions (and gain a few new ones!), and design things that you couldn't produce otherwise. We're entering uncharted territory and I love it.
As far as I know there is a concept that is by far older:
Combat aircraft, even in WW2, where designed with textile outer body over a wooden skeleton (some DIY kits are made this way today).
The moveable skeleton is the most exiting.